Rudolf Zechner Selected Research

Lipase (Acid Lipase)

1/2022	Small-Molecule Inhibitors Targeting Lipolysis in Human Adipocytes.
1/2020	The Role of Adipose Triglyceride Lipase and Cytosolic Lipolysis in Cardiac Function and Heart Failure.
1/2020	Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling.
10/2018	Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase.
1/2018	Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase.
1/2017	Corrigendum: Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
1/2017	Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
6/2016	Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.
6/2014	Endothelial dysfunction in adipose triglyceride lipase deficiency.
4/2014	Fat-specific protein 27 (FSP27) interacts with adipose triglyceride lipase (ATGL) to regulate lipolysis and insulin sensitivity in human adipocytes.

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Rudolf Zechner Research Topics

Disease

19	Insulin Resistance 01/2022 - 10/2002
9	Neoplasms (Cancer) 01/2022 - 07/2011
8	Inflammation (Inflammations) 01/2022 - 08/2011
8	Obesity 01/2022 - 10/2002
7	Cardiomyopathies (Cardiomyopathy) 01/2017 - 02/2003
6	Heart Failure 01/2022 - 08/2013
5	Non-alcoholic Fatty Liver Disease 01/2020 - 08/2013
5	Atherosclerosis 01/2011 - 01/2002
4	Fatty Liver 01/2022 - 02/2011
4	Cachexia 01/2019 - 07/2011
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 05/2006
2	Heart Diseases (Heart Disease) 01/2022 - 12/2014
2	Body Weight (Weight, Body) 01/2021 - 08/2003
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 05/2006
2	Metabolic Diseases (Metabolic Disease) 01/2019 - 11/2017
2	Hypoxia (Hypoxemia) 01/2018 - 07/2014
2	Weight Gain 01/2017 - 05/2011
2	Myocardial Ischemia (Ischemic Heart Diseases) 12/2014 - 01/2003
2	Neutral Lipid Storage Disease with Myopathy 03/2013 - 12/2010
2	Ichthyosis (Xeroderma) 01/2012 - 03/2010
1	Atrophy 01/2022
1	Shock 10/2021
1	Ataxia (Dyssynergia) 01/2019
1	Gliosis 01/2019
1	Huntington Disease (Huntington's Disease) 01/2019
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2018
1	Hypertriglyceridemia 01/2017
1	Choristoma (Ectopic Tissue) 01/2017
1	Prostatic Neoplasms (Prostate Cancer) 01/2017
1	Adenocarcinoma 06/2016
1	Lung Neoplasms (Lung Cancer) 06/2016
1	Leiomyosarcoma 06/2016
1	Starvation 07/2015
1	Endotoxemia 03/2014
1	Necrosis 11/2013
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2013
1	Diabetic Cardiomyopathies 05/2013
1	Liver Cirrhosis (Hepatic Cirrhosis) 05/2012
1	Fibrosis (Cirrhosis) 01/2012
1	Hepatocellular Carcinoma (Hepatoma) 10/2011
1	Mitochondrial Diseases (Mitochondrial Disease) 08/2011

Drug/Important Bio-Agent (IBA)

17	Lipase (Acid Lipase)FDA Link 01/2022 - 05/2006
16	LipidsIBA 11/2017 - 03/2003
15	Triglycerides (Triacylglycerol)IBA 11/2017 - 03/2003
10	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 08/2003
9	Proteins (Proteins, Gene)FDA Link 10/2021 - 12/2010
8	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 08/2003
8	EnzymesIBA 06/2016 - 10/2002
6	Sterol Esterase (Hormone-Sensitive Lipase)IBA 01/2021 - 06/2003
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 07/2014 - 08/2011
4	Insulin (Novolin)FDA Link 08/2013 - 08/2003
3	CytokinesIBA 01/2019 - 01/2014
3	HydrolasesIBA 01/2017 - 01/2012
3	Interleukin-6 (Interleukin 6)IBA 09/2014 - 01/2011
2	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022 - 09/2014
2	atglistatinIBA 10/2018 - 01/2017
2	Cholesterol Esters (Cholesteryl Esters)IBA 01/2017 - 10/2010
2	Nonesterified Fatty Acids (NEFA)IBA 04/2014 - 05/2006
2	adiponutrinIBA 05/2012 - 02/2011
2	Lipoproteins (Lipoprotein)IBA 06/2003 - 03/2003
2	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 10/2002 - 01/2002
1	Pharmaceutical PreparationsIBA 01/2022
1	Interleukin-4 Receptors (Interleukin 4 Receptor)IBA 01/2022
1	Dopamine (Intropin)FDA LinkGeneric 01/2022
1	CatecholaminesIBA 01/2022
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2022
1	MonoglyceridesIBA 03/2020
1	Adenylate KinaseIBA 01/2020
1	CannabinoidsIBA 01/2019
1	bis(monoacylglyceryl)phosphateIBA 01/2019
1	JZL 184IBA 01/2019
1	AcidsIBA 11/2017
1	T0901317IBA 01/2017
1	Messenger RNA (mRNA)IBA 06/2016
1	DiglyceridesIBA 01/2016
1	RetinoidsIBA 07/2015
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2014
1	Arachidonic Acid (Vitamin F)IBA 12/2014
1	UbiquitinIBA 12/2014
1	Fenofibrate (CiL)FDA LinkGeneric 03/2014
1	DNA (Deoxyribonucleic Acid)IBA 03/2014
1	Choline (Choline Chloride)IBA 03/2014
1	LipopolysaccharidesIBA 03/2014
1	Methionine (L-Methionine)FDA Link 03/2014
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2014
1	Tumor Biomarkers (Tumor Markers)IBA 11/2013
1	Galectin 3 (LGALS3)IBA 11/2013
1	Streptozocin (Streptozotocin)FDA Link 05/2013
1	BezafibrateIBA 03/2013
1	12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme AIBA 01/2012
1	Bile Acids and Salts (Bile Acids)IBA 01/2012
1	ATP-Binding Cassette Sub-Family B Member 4IBA 01/2012
1	Phospholipases (Phospholipase)IBA 01/2012
1	24-norursodeoxycholic acidIBA 01/2012
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2011
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 10/2011
1	Growth Hormone (Somatotropin)IBA 10/2011
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2011

Therapy/Procedure

1	Therapeutics 10/2018
1	Sympathectomy (Sympathectomies) 01/2012